1950
D.O.A. is a film noir directed by Rudolph Maté, and is considered a classic of the genre. The frantically-paced plot revolves around a doomed man's quest to find out who has poisoned him – and why – before he dies.
The shot of Edmond O'Brien running down Market Street (between 4th and 6th Streets) in San Francisco was a "stolen shot," taken without city permits, with some pedestrians visibly confused as O'Brien bumps into them.
This film is available online as a free download.